SILDENAFIL CITRATE DOES NOT INTERFERE WITH BLOOD PRESSURE MEDICATION
Title: SILDENAFIL CITRATE DOES NOT INTERFERE WITH BLOOD PRESSURE MEDICATION , By: Greer, Michael, Blood Weekly, 10656073, 02/08/2001
Section: Expanded Reporting
Hypertension
2001 FEB 8 - (NewsRx.com & NewsRx.net) — Men on medication for hypertension do not suffer dangerous increases in blood pressure during treatment with the popular erectile dysfunction drug sildenafil citrate (Viagra), cardiologists report.
R.M. Zusman and colleagues at Massachusetts General Hospital performed a study to “assess the acute effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication.”
The researchers enrolled more than 1,600 men who had suffered from at least six months of erectile dysfunction, comparing blood pressure levels in those whose were also being treated for hypertension and those who weren’t (”Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication,” Journal of Hypertension, 2000;18(12):1865-1869).
There was no significant variation in resting systolic or diastolic blood pressure between men who were given both antihypertension medication and sildenafil citrate or given a sildenafil citrate placebo, the researchers reported.
Moreover, the average changes in baseline heart rate were also virtually identical between these two groups of patients, study data showed. Similarly, the researchers found little variation in the blood pressure and heart rates of men treated with sildenafil citrate and either antihypertensive medicine or a placebo.
“The acute, short-term effects of oral sildenafil on blood pressure and heart rate in men with erectile dysfunction were small and not likely to be clinically significant in those taking concomitant antihypertensive medication,” Zusman and colleagues concluded.
The contact person for this report is R.M. Zusman, Massachusetts General Hospital, Cardiac Unit, 15 Parkman St., WACC 482, Boston, MA 02114 USA.
Key points reported in this study include:
- Hypertensive men do not suffer dangerous increases in blood pressure during sildenafil citrate treatment
- Similarly, no significant increase in heart rate was observed in hypertensive men during therapy
- Researchers concluded that sildenafil citrate is safe for men taking antihypertensive medication
This article was prepared by Blood Weekly editors from staff and other reports.
~~~~~~~~
By Michael Greer, Staff Medical Writer
Copyright of Blood Weekly is the property of NewsRx and its content may not be copied or e-mailed to multiple sites or posted to a listserv without the copyright holder`s express written permission. However, users may print, download, or e-mail articles for individual use.
Source: Blood Weekly, 02/08/2001, p10, 1p
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